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Important
Safety Information
Mild reactions at the injection site, such as pain, redness, swelling, or induration, are possible. More marked local reactions, such as fever, headache, myalgia, lymph node swelling, fatigue, arthritis, and gastrointestinal disorders, may occasionally occur.
Rare are circulatory reactions, sweating, chills, paraesthesia and allergic reactions; these require treatment only in exceptional cases. There have been isolated reports of inflammatory and demyelinating neurological disorders, such as progressive ascending paralysis (Guillain-Barré syndrome) or optic neuritis in individual cases.
Based on currently available data, it cannot be completely excluded that, in rare cases, immunisation may induce an acute episode in patients with an autoimmune disorder (such as multiple sclerosis) or with an appropriate genetic predisposition. However, there is no evidence of an increased frequency of autoimmune disorders after immunisation.
If you develop side effects, especially those not mentioned, please inform your doctor or pharmacist.
Approved Use
Active immunization against rabies
Pre-exposure immunisation (preventative, prior to exposure)
Immunisation prior to possible infection with rabies, particularly for vets, veterinary medicine students, animal keepers, hunters, forestry workers, animal handlers, butchers, personnel in rabies research laboratories, etc., or prior to visits to areas in which rabies is endemic (rabies-infected areas).
Post-exposure treatment (after exposure)
Treatment after contact with animals which are rabid or suspected to be rabid, or after contact with an inoculated rabies carcass.
People with a compromised immune system
If you/your child has an increased risk of rabies infection because your immune system is not working correctly, you/your child will need five or six doses (each of 1.0 ml) of rabies vaccine after contact with a rabid or suspected rabid animal. Vaccination is given in combination with local treatment of the wound and rabies immunoglobulin.
If six doses are used, the first two are given as soon as possible after the contact, and then single doses are given on days 3, 7, 14 and 28 after the first dose.
If five doses are used, the first dose is given as soon as possible after the contact, and the others are given on days 3, 7, 14 and 28 after the first dose.
It may also be necessary for you/your child to have blood tests to measure the amount of antibodies to the rabies virus in your/your child’s blood so that extra vaccine doses can be given if needed. Your doctor will explain what needs to be done and tell you when to attend extra tests or doses.